BEGIN:VCALENDAR VERSION:2.0 PRODID:-//142.1.176.100//NONSGML kigkonsult.se iCalcreator 2.26.9// CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Chemical Engineering &\; Applied Chemistry X-WR-CALDESC: X-FROM-URL:https://chem-eng.utoronto.ca X-WR-TIMEZONE:America/Toronto BEGIN:VTIMEZONE TZID:America/Toronto X-LIC-LOCATION:America/Toronto BEGIN:STANDARD DTSTART:20231105T020000 TZOFFSETFROM:-0400 TZOFFSETTO:-0500 RDATE:20241103T020000 TZNAME:EST END:STANDARD BEGIN:DAYLIGHT DTSTART:20240310T020000 TZOFFSETFROM:-0500 TZOFFSETTO:-0400 RDATE:20250309T020000 TZNAME:EDT END:DAYLIGHT END:VTIMEZONE BEGIN:VEVENT UID:ai1ec-24483@chem-eng.utoronto.ca DTSTAMP:20240329T071721Z CATEGORIES: CONTACT:Siewan Chan\; adminshoichet@utoronto.ca DESCRIPTION:Abstract:\nThe extracellular matrix directs stem cell function through a complex choreography of biomacromolecular interactions in a tiss ue-dependent manner. Far from static\, this hierarchical milieu of biochem ical and biophysical cues presented within the native cellular niche is bo th spatially complex and ever changing. As these pericellular reconfigurat ions are vital for tissue morphogenesis\, disease regulation\, and healing \, in vitro culture platforms that recapitulate such dynamic environmental phenomena would be invaluable for fundamental studies in stem cell biolog y\, as well as in the eventual engineering of functional human tissue. In this talk\, I will discuss some of our group’s recent successes in reversi bly modifying both the chemical and physical aspects of synthetic cell cul ture platforms with user-defined spatiotemporal control\, regulating cell- biomaterial interactions through user-programmable Boolean logic\, and eng ineering microvascular networks that span nearly all size scales of native human vasculature (including capillaries). Results will highlight our abi lity to modulate intricate cellular behavior including stem cell different iation\, protein secretion\, and cell-cell interactions in 4D.\nBiography: \nDr. Cole A. DeForest is the Weyerhaeuser Endowed Associate Professor in the Departments of Chemical Engineering and Bioengineering\, the Associate Chair of Chemical Engineering\, as well as a core faculty member of the I nstitute for Stem Cell & Regenerative Medicine at the University of Washin gton (UW) where he began in 2014. He received his B.S.E. degree from Princ eton University in 2006\, majoring in Chemical Engineering and minoring in Material Science Engineering and Bioengineering. He earned his Ph.D. degr ee under the guidance of Dr. Kristi Anseth from the University of Colorado in Chemical and Biological Engineering with an additional certificate in Molecular Biophysics. His postdoctoral research was performed with Dr. Dav id Tirrell in the Divisions of Chemistry and Chemical Engineering at the C alifornia Institute of Technology. He has published >60 peer-reviewed arti cles\, including as the corresponding author for those appearing in Nature Materials\, Nature Chemistry\, Advanced Materials\, JACS\, PNAS\, Science Advances\, and Nature Reviews Materials. Dr. DeForest has received numero us research awards and honors including the Society for Biomaterials Young Investigator Award (2020)\, NIH Maximizing Investigators’ Research Award (MIRA R35\, 2020)\, Safeway Early Career Award (2018)\, NSF CAREER Award ( 2017)\, AIChE 35-Under-35 Award (2017)\, ACS PMSE Young Investigator Award (2017)\, Jaconette L. Tietze Young Scientist Award (2015)\, Biomedical En gineering Society Student Fellow Award (2013)\, DSM Polymer Technology Awa rd (2011)\, ACS Excellence in Graduate Polymer Research Award (2010)\, MRS Graduate Student Research Gold Award (2009)\, Society for Biomaterials Ou tstanding Achievement Award (2009)\, Princeton University Material Science Student of the Year (2006)\, Princeton University Most Approachable Resid ent Adviser (2005)\, and Boulder High School Valedictorian (2002). Notably \, he has also been recognized for excellence in teaching and was awarded the UW Presidential Distinguished Teaching Award (2016)\, given annually t o a single Assistant Professor across all of the UW. His research has been supported through fellowships and grants from the National Science Founda tion\, the National Institutes of Health\, and the US Department of Educat ion.\nPlease contact adminshoichet@utoronto.ca for the Zoom information. DTSTART;TZID=America/Toronto:20220825T113000 DTEND;TZID=America/Toronto:20220825T123000 LOCATION:Red Seminar Room\, Donnelly Centre @ 250-160 College Street SEQUENCE:0 SUMMARY:Special Seminar: User-Programmable Hydrogel Biomaterials to Probe a nd Direct 4D Stem Cell Fate URL:https://chem-eng.utoronto.ca/event/special-seminar-user-programmable-hy drogel-biomaterials-to-probe-and-direct-4d-stem-cell-fate/ X-COST-TYPE:free X-ALT-DESC;FMTTYPE=text/html:\\n\\n
\\nAbstract:
\nThe extracellular matrix directs stem cell function through a complex ch oreography of biomacromolecular interactions in a tissue-dependent manner. Far from static\, this hierarchical milieu of biochemical and biophysical cues presented within the native cellular niche is both spatially complex and ever changing. As these pericellular reconfigurations are vital for t issue morphogenesis\, disease regulation\, and healing\, in vitro culture platforms that recapitulate such dynamic environmental phenomena would be invaluable for fundamental studies in stem cell biology\, as well as in th e eventual engineering of functional human tissue. In this talk\, I will d iscuss some of our group’s recent successes in reversibly modifying both t he chemical and physical aspects of synthetic cell culture platforms with user-defined spatiotemporal control\, regulating cell-biomaterial interact ions through user-programmable Boolean logic\, and engineering microvascul ar networks that span nearly all size scales of native human vasculature ( including capillaries). Results will highlight our ability to modulate int ricate cellular behavior including stem cell differentiation\, protein sec retion\, and cell-cell interactions in 4D.
\nBiography:
\nDr. Cole A. DeForest is the Weyerh aeuser Endowed Associate Professor in the Departments of Chemical Engineer ing and Bioengineering\, the Associate Chair of Chemical Engineering\, as well as a core faculty member of the Institute for Stem Cell & Regenerativ e Medicine at the University of Washington (UW) where he began in 2014. He received his B.S.E. degree from Princeton University in 2006\, majoring i n Chemical Engineering and minoring in Material Science Engineering and Bi oengineering. He earned his Ph.D. degree under the guidance of Dr. Kristi Anseth from the University of Colorado in Chemical and Biological Engineer ing with an additional certificate in Molecular Biophysics. His postdoctor al research was performed with Dr. David Tirrell in the Divisions of Chemi stry and Chemical Engineering at the California Institute of Technology. H e has published >60 peer-reviewed articles\, including as the correspondin g author for those appearing in Nature Materials\, Nature Chemistry\, Adva nced Materials\, JACS\, PNAS\, Science Advances\, and Nature Reviews Mater ials. Dr. DeForest has received numerous research awards and honors includ ing the Society for Biomaterials Young Investigator Award (2020)\, NIH Max imizing Investigators’ Research Award (MIRA R35\, 2020)\, Safeway Early Ca reer Award (2018)\, NSF CAREER Award (2017)\, AIChE 35-Under-35 Award (201 7)\, ACS PMSE Young Investigator Award (2017)\, Jaconette L. Tietze Young Scientist Award (2015)\, Biomedical Engineering Society Student Fellow Awa rd (2013)\, DSM Polymer Technology Award (2011)\, ACS Excellence in Gradua te Polymer Research Award (2010)\, MRS Graduate Student Research Gold Awar d (2009)\, Society for Biomaterials Outstanding Achievement Award (2009)\, Princeton University Material Science Student of the Year (2006)\, Prince ton University Most Approachable Resident Adviser (2005)\, and Boulder Hig h School Valedictorian (2002). Notably\, he has also been recognized for e xcellence in teaching and was awarded the UW Presidential Distinguished Te aching Award (2016)\, given annually to a single Assistant Professor acros s all of the UW. His research has been supported through fellowships and g rants from the National Science Foundation\, the National Institutes of He alth\, and the US Department of Education.
\nPlease contact adminshoichet@utoronto.ca for the Z oom information.
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