Christopher Lawson

Chris LawsonAssistant Professor
B.A.Sc., M.A.Sc. (UBC), Ph.D. (Wisconsin), Post-doc (Berkeley Lab)
Principal Investigator, Microbiome Engineering Lab and BioZone — Centre for Applied Bioscience and Bioengineering
Room: 412 | Email:  | Website:



  • ISME/IWA BioCluster Rising Star Award (2022)
  • Jacobs Engineering Group/AEESP Outstanding Doctoral Dissertation Award (2020)
  • Wesley Eckenfelder Graduate Research Award (2019)
  • WEF Canham Graduate Studies Scholarship (2018)
  • NSERC Post-Graduate Scholarship – Doctoral (2014)


  • International Society for Microbial Ecology (ISME)
  • American Society for Microbiology (ASM)
  • International Water Association (IWA)
  • Association of Environmental Engineering & Science Professors (AEESP)

Research Interests

Research Interests: microbiome engineering, systems biology, synthetic biology, microbial ecology, machine learning, biological waste treatment, resource recovery, environmental biotechnology.

Society has enormous potential to recover renewable bioenergy and bioproducts from waste streams, while simultaneously reducing waste disposal impacts and our dependance on fossil fuels. Unlocking this potential will require bioengineering innovation to commoditize renewable energy, chemicals, and materials from waste streams at industrial scales. Revolutionary advances in systems and synthetic biology are positioned to make these innovations possible, as breakthroughs in metagenomic sequencing, high-resolution mass spectrometry, and genome editing have opened a window into the metabolic and regulatory networks driving microbial community (“microbiome”) functions, extending from single genes to whole ecosystems. However, incorporating these developments into biotechnologies at scale has been limited by the high complexity of microbe-microbe interactions and the lack of tools to manipulate microbiome assembly and function in a precise manner.

My research seeks to create novel anaerobic biotechnologies that recover valuable resources (energy, chemicals, materials) from waste streams using systems and synthetic biology approaches. This will enable a fundamental understanding of microbiome assembly and function and contribute transformative wastewater treatment and solid waste management technologies aimed at building a circular bioeconomy.

Systematic engineering of microbiomes for resource recovery

Our lab is devoted to creating new microbiome engineering approaches to recover a wider range of high-value bioproducts from wastes. While microbiome engineering has traditionally relied on selection (e.g. manipulation of environmental variables) to steer biological processes towards a desired function, this approach results in highly complex communities that offer little control over the specific products that can be made. We are developing high-throughput methods that integrate automation, synthetic biology, and machine learning to create engineered microbiomes that recover a broad range of bioproducts from waste streams at commercially viable titers, rates, and yields. Our main objectives in this area are 1) systematic assembly and analysis of synthetic anaerobic microbiomes to produce valuable chemicals and 2) metabolic engineering of diverse non-model anaerobic microorganisms to optimize flux through microbiome metabolic networks.

Metabolic regulation of anaerobic microbiome metabolism

Despite decades of investigations into anaerobic microbiome metabolism, our ability to predict the interwoven metabolic networks driving organic matter conversion to bioproducts remains insufficient for bioengineering. This is because existing approaches fail to establish quantitative and causal links between feedstock chemistry, process rates and conditions, and in situ activity (i.e. fluxes) of microbiome metabolic networks. This makes it challenging to accelerate process reaction rates, maximize bioproduct yields, predict process stability, and assess process performance under different operational strategies in a rational manner. Our lab will focus on the systems-level analysis of metabolic regulation in anaerobic microbiomes and associated anaerobic microorganisms involved in converting wastes into bioproducts, using state-of-the-art metabolomic and metaproteomic approaches coupled to isotope tracing and quantitative metabolic modeling. Our main research objectives in this area are 1) quantitative understanding of microbiome metabolism remodeling during different feeding and operational strategies, 2) metabolic regulation in non-model anaerobic microorganisms involved in waste deconstruction and conversion, and 3) elucidating metabolic interactions and fluxes in anaerobic microbiomes.

Selected Publications:

Sánchez-Andrea I., Alves Guedes I., Hornung B., Boeren S., Lawson C.E., Sousa D.Z., Bar-Even A., Claassens N.J., Stams A.J.M. (2020). The reductive glycine pathway allows autotrophic growth of Desulfovibrio desulfuricans. Nature Communications 11: 5090.

Lawson, C.E., Harcombe, W.R., Hatzenpichler, R., Lindmann, S.R., Löffler, F., O’Malley, M.A., García-Martin, H., Pfleger, B.F., Raskin, L., Venturelli, O.S., Weissbrodt, D.G., Noguera, D.R., McMahon, K.D. (2019) Common principles and best practice for engineering microbiomes. Nature Reviews Microbiology 17: 725–741.

Mundinger, A., Lawson, C.E., Koch, H., Jetten, M.S.M., Lücker, S. (2019) Cultivation and Transcriptional Analysis of a Canonical Nitrospira Under Stable Growth Conditions. Frontiers in Microbiology 10: 1325.

Scarborough, M.J., Lawson, C.E., Hamilton, J.J., Donohue, T.J., Noguera, D.R. Metatranscriptomic and thermodynamic insights into medium-chain fatty acid production using an anaerobic microbiome. mSystems 3(6): e00221-18.

Lawson, C.E., Lücker S. (2018). Complete ammonia oxidation: an important control on nitrification in engineered ecosystems? Current Opinion in Biotechnology 50: 158-165.

Lawson, C.E., Wu, S., Bhattacharjee, A.S., Hamilton, J.J., McMahon, K.D., Goel, R., Noguera, D.R. (2017) Metabolic network analysis reveals microbial community interactions in anammox granules. Nature Communications 8:15416.

Oyserman, B.O., Moya, F., Lawson, C.E., Garcia, A.L., Voigt, M., Heffernan, M., Noguera, D.R., McMahon, K.D. (2016) Ancestral genome reconstruction identifies the evolutionary basis for trait acquisition in polyphosphate accumulating bacteria. The ISME Journal 10: 2931-2945.

Lawson, C.E., Strachan, C.R., Williams, D.D., Koziel, S., Hallam, S.J., and Budwill, K. (2015) Patterns of endemism and habitat selection in coalbed microbial communities. Appl. Environ. Microbiol. 81: 7924–7937.

Lawson, C.E., Strachan, B.J., Hanson, N.W., Hahn, A.S., Hall, E.R., Rabinowitz, B., Mavinic, D.S., Ramey, W.D., Hallam, S.J. (2015) Rare taxa have potential to make metabolic contributions in enhanced biological phosphorus removal ecosystems. Environ. Microbiol. 17: 4979–4993.

Pabst M., Grouzdev, D., Lawson C.E., Kleikamp H.B.C., de Ram, C., Louwen, R., Lin Y., Lucker, S., van Loosdrecht, M., Laureni, M. A general approach to explore prokaryotic protein glycosylation reveals the unique surface layer modulation of an anammox bacterium. The ISME Journal 16, 346–357.

Scarborough, M.J., Lawson, C.E., Decola, A.C., Gois, I.M. (2022). Microbiomes for sustainable biomanufacturing. Curr. Opin. Microbiol. 65, 8-14.

Lawson, C.E., Mundinger, A.B., Koch, H., Jacobson, T.B., Weathersby, C.A., Jetten M.S.M., Pabst M., Amador-Noguez D., Noguera, D.R., McMahon, K.D., Lücker S. (2021). Investigating the chemolithoautotrophic and formate metabolism of Nitrospira moscoviensis by constraint-based metabolic modeling and 13C-tracer analysis. mSystems, 6(4) e00173-21.

Lawson, C.E., Nuijten, G., de Graaf, R., Jacobson, T.B., Pabst, M., Stevenson, D.M., Jetten, M.S.M., Noguera, D.R., McMahon, K.D., Amador-Noguez, D., Lücker, S. (2021) Autotrophic and mixotrophic metabolism of an anammox bacterium revealed by in vivo 13C and 2H metabolic network mapping. The ISME Journal 15 (3), 673-687.

Cerruti, M., Guo, B., Delatolla, R., De Jonge, N., De Vos Van Steenwijk, A.H., Kadota, P., Lawson, C.E., Mao, T., Oosterkamp, M.J., Sabba, F., Stokholm-Bjerregaard M., Watson, I., Frigon, D., Weissbrodt, D.G. (2021). Plant-wide systems microbiology for the wastewater industry. Environmental Science: Water Research & Technology. 7(10): 1687-1706.

Lawson, C.E. (2021). Retooling Microbiome Engineering for a Sustainable Future. mSystems. 6(4): e00925-21.

Wilken E, Monk J, Leggieri P, Lawson C.E., Lankiewicz T, Seppala S, Daum C, Jenkins J, Lipzen A, Mondo S, Barry K, Grigoriev I, Henske J, Theodorou M, Palsson B, Petzold L, O'Malley M. (2020). Experimentally validated reconstruction and analysis of a genome-scale metabolic model of an anaerobic Neocallimastigomycota fungus. mSystems 6 (1), e00002-21.