200 College St
Toronto, ON M5T 3A1
BioZone and the Faculty of Applied Science & Engineering are very pleased to be able to invite you to an Open House that will showcase the services available at the BioZone Mass Spectrometry Facility. The Mass Spectrometry Facility operates at the University of Toronto in the Department of Chemical Engineering & Applied Chemistry and offers proteomics, metabolomics, and small molecule analysis, as well as method development services and expert advice on these techniques.
The purpose of this event is to promote discussion on the potential uses of mass spectrometry in order to solve complex research questions and to promote the development of novel and relevant mass spectrometry protocols.
Registration required. To register, visit https://www.eventbrite.ca/e/biozone-mass-spectrometry-facility-open-house-tickets-25705854904
At the Open House you will learn about:
- Exciting new developments in mass spectrometry-based proteomics, small molecule analysis and metabolomics;
- How mass spectrometry can support research and product development;
- The types of analysis supported at the BioZone Mass Spectrometry Facility;
- Starting material requirements, sample preparation, and protocol development.
- 09:00 – Keynote: Decoding metabolic evolution by high-resolution mass spectrometry – Professor Ian Lewis
- 09:45 – Capabilities and use of BioZone Mass Spec
- 10:15 – Case studies 1 (Professor Arthur Chan and More)
- 10:45 – Break
- 11:00 – Case Studies 2 (Professor Adam Rosebrock and more)
- 11:45 – Open Discussion
- 12:30 – Tour
- 12:45 – Lunch and Networking
Decoding metabolic evolution by high-resolution mass spectrometry
The fundamental nutritional requirements of cells are common to almost all living organisms. However, evolutionary pressures have radically diversified the strategies organisms use to meet these demands. One of the most extreme contrasts in nutritional strategies can be found in host-pathogen metabolic exchanges. Host organisms supply a predictable supply of nutrients to their cells despite dietary diversity, unpredictable energy output, and famine. Pathogens, by contrast, avoid nutritional adversity by stealing from their host. The nutrients pathogens come to rely on, and their strategies for acquiring these molecules, have a direct bearing on the severity and clinical presentation of infections. The Lewis laboratory specializes in unraveling these complex host/pathogen metabolic interactions using high-resolution mass spectrometry and multidimensional nuclear magnetic resonance spectroscopy. I will discuss the unique challenges one must overcome when unravelling these complex multi-organism metabolic systems and describe how the unique metabolic selective forces have shaped the evolution of human pathogens.